The Best Joint Supplements to Fight Pain

Many individuals experience the burden of knee discomfort and achy joints. According to a recent survey conducted by the University of Michigan, it was shown that a significant proportion, namely 70%, of individuals aged 50 and above, have intermittent occurrences of joint discomfort. Joints, also known as articulations, are the anatomical sites where two or more bones are interconnected, facilitating various forms of locomotion such as running, walking, jumping, engaging in sports, and performing routine tasks.

The aging process inherently impacts the condition of one’s joints. However, the significance of diet in maintaining joint health and strength is significant. Maintaining a diet abundant in anti-inflammatory foods and high in nutrients is crucial for promoting optimal joint health. However, it is worth noting that adding certain nutrients such as glucosamine, MSM, and chondroitin may relieve some symptoms associated with joint health issues.

If someone has been experiencing discomfort in their knee or stiffness in their other joints, they are not the only ones facing this issue. As per the findings of the US Centers for Disease Control and Prevention, around 15 million individuals in the United States who have arthritis endure intense joint pain, with almost double that number reporting its enduring nature. The significance of maintaining one’s physical well-being, particularly with advancing age, cannot be overstated.

Maintaining bone and joint health may be achieved via adopting a healthy lifestyle, which encompasses consuming nutritionally balanced food and participating in low-impact physical activities. Additionally, individuals may consider identifying and using one of the best joint supplements to support their bone and joint well-being. There are a variety of supplements that contribute to the promotion of joint health. In the following discussion, we will explore many vitamins and joint health supplements that have been shown to contribute to the maintenance of bone and joint health, therefore perhaps alleviating the discomfort experienced during mornings.

Best joint supplements

Several of the most effective joint supplements contain chemicals naturally in the human body. Acquire more knowledge on the optimal vitamins for joint health.


Collagen is a fibrous protein found in the extracellular matrix of various animal tissues,
Collagen, a protein synthesized endogenously by the human body, gradually declines production as an individual ages. Collagen is responsible for maintaining the tautness and elasticity of the skin and ensuring the proper functioning of joints. As individuals age, the collagen concentration in their joints diminishes, potentially necessitating joint supplements for remedial purposes. The current body of research on the efficacy of collagen in improving joint health is limited. However, medical professionals generally believe collagen supplementation is unlikely to have adverse effects. It is viable if collagen intake is accompanied by low-impact physical activities such as swimming and contributes to an individual’s subjective well-being. The administration of this supplement is usually considered safe since the associated adverse effects are often modest, including symptoms such as stomach pain or diarrhea. Nevertheless, it is essential to use caution when selecting substances since the Food and Drug Administration does not oversee monitoring.

Omega-3 fatty acids

Omega-3 fatty acids have the potential to mitigate inflammation and reduce joint discomfort. Numerous studies have shown the potential of these supplements to alleviate stiffness in those suffering from arthritis and mitigate joint pain. Multiple investigations have examined the mechanisms by which omega-3 fatty acids interact with arthritis. Empirical evidence has substantiated the capacity of this particular lipid to impede the onset of experimental arthritis and perhaps mitigate the severity of symptoms in individuals with rheumatoid arthritis. Omega-3 fatty acids are generally considered a healthy dietary supplement; nonetheless, they have been associated with potential adverse effects such as heartburn, nausea, and diarrhea. Consult with a doctor before incorporating omega-3 supplementation into one’s regimen if they are presently on anticoagulant therapy since there is minimal potential for hemorrhagic complications when these two interventions are concomitantly administered.


Glucosamine is a naturally occurring compound. Glucosamine is endogenously present in the human body. Cartilage is a structural component inside the human body that plays a vital role in facilitating the proper functioning of joints. It is widely accepted that the administration of a glucosamine supplement may alleviate the symptoms associated with arthritis, namely by reducing the pain experienced in cases of osteoarthritis or rheumatoid arthritis. Due to its endogenous nature, ingesting a supplement is typically considered safe. The administration of this substance has the inherent risk of inducing adverse effects such as nausea and heartburn. Additionally, those with a known shellfish allergy should exercise caution and refrain from its use. Additionally, drug interaction with anticoagulants is potentially dangerous, which may result in bleeding-related complications.

Vitamin D

Vitamin D is a micronutrient crucial to maintaining overall health and well-being. Vitamin D is recognized for promoting skeletal health, leading to the belief that a vitamin D supplement may benefit joint health. Several studies have shown a possible association between using vitamin D supplements and alleviating arthritis-related pain and inflammation. However, it is essential to note that the findings do not unequivocally provide a conclusive response to this matter. Nevertheless, this dietary supplement may assist.

Vitamin D is a valuable nutrient that plays a crucial role in calcium retention, contributing to dental health. It is advisable to use caution while including a vitamin D supplement in one’s daily regimen since excessive quantities of this particular vitamin may potentially interfere with several medications. Significantly, elevated vitamin D concentrations pose considerable challenges when concurrently administered with Lanoxin, potentially predisposing individuals to hypercalcemia. The co-administration of other pharmaceuticals with a vitamin D supplement may impact the metabolic processing of the supplement inside the human body.


Chondroitin is a naturally occurring glycosaminoglycan that is commonly found. Chondroitin is often referenced in conjunction with glucosamine due to its comparable nature. Chondroitin is present within the human body’s cartilaginous tissues, supposing that it has advantageous properties in enhancing the well-being of joints. The research on chondroitin has shown mostly equivocal findings, yet it is widely acknowledged as a potential supplement that may benefit joint health. The supplement is often seen as safe; nevertheless, similar to several other supplements, it has the potential to interact with Warfarin, hence increasing the likelihood of bleeding complications.

Vitamin E

It is a fat-soluble nutrient that is essential for human health. Due to its antioxidant properties, many individuals rely on vitamin E to bolster their immune systems. Nevertheless, extant research has explored the potential of vitamin E in decelerating the advancement of osteoarthritis and facilitating the proliferation of nascent cartilage cells. Regardless, a significant portion of these findings requires more investigation. Vitamin E is a beneficial dietary supplement because it supports optimal visual acuity and cognitive function. Acknowledging the potential for interaction between this substance and blood thinners is important, which may increase the likelihood of experiencing bleeding complications.

Nordic Naturals

Nordic Naturals, a well-known brand recognized for its extensively researched fish oil supplements, provides a meticulously formulated high-quality complex designed to promote optimal joint health. The product contains 1,065 milligrams of omega-3 fatty acids.
The composition of this complex comprises 1,500 milligrams of glucosamine sulfate, a naturally occurring chemical present in cartilage, which serves as the protective tissue for joints. Glucosamine sulfate can alleviate symptoms associated with osteoarthritis and Rheumatoid arthritis. According to the study, denatured type II collagen emerges as a significant factor in this context, surpassing the efficacy of glucosamine or chondroitin sulfate supplementation in promoting joint health. This efficacious compound specifically focuses on restoring cartilage and reconstructing robust joints and is derived only from wild-caught sardines and anchovies.

Deva Vegan Glucosamine

This Deva alternative is a terrific choice if you’re looking for a glucosamine supplement alone. You must take three tablets daily to acquire the recommended daily allowance of glucosamine (1,500 mg).
This supplement is cruelty-free since the glucosamine is derived from non-GMO maize rather than shellfish, which is the standard practice for most glucosamine supplements. The Vegan Society has confirmed that this glucosamine supplement does not test on animals and may be safely consumed by vegans and vegetarians.

Solgar Glucosamine, Hyaluronic Acid, Chondroitin, MSM

This superior product from Solgar has all the key ingredients you need for joint health. There are also chondroitin and MSM in addition to the glucosamine. Hyaluronic acid is another novel component of this mixture; it is a gel-like material that aids in joint lubrication and the development of cartilage and bone. You may get it in injectable form, but you can also get it as oral supplements that help reduce joint inflammation.
This complex does not serve seafood or use artificial flavors, sweeteners, preservatives, or colors.
Solgar is proud of its rigorous 30-minute testing intervals that occur at key points in the production process. In addition to using USP water and HEPA air filtration, these vitamins are hand-made in the USA from the highest quality components.

NOW Vegetarian Glucosamine & MSM

This supplement contains both glucosamine, the main component of cartilage tissue, and methylsulfonylmethane (MSM), an organic form of sulfur that may reduce pain and swelling and improve symptoms in people with osteoarthritis, especially when combined with glucosamine.
This product’s glucosamine is made from non-GMO maize, although it does need three capsules of very big tablets. It is inexpensive per dose yet of great quality. If you don’t require a vegetarian alternative, this complex is also available with chondroitin sulfate from cow cartilage. Chondroitin sulfate is a cartilage-building ingredient typically incorporated in supplements alongside glucosamine for osteoarthritis pain treatment.

Life Extension ArthroMax Advanced

Collagen is essential for forming and stabilizing connective tissues, particularly the cartilage that protects your joints. Type II cartilage, in particular, has improved joint health in osteoarthritic patients and should not be confused with collagen peptides, type I collagen, or gelatin.
This non-GMO joint-specific supplement from Life Extension includes undenatured type II collagen, glucosamine, and boswellia, which limited evidence shows may ease joint pain and boron. This mineral has a role in building healthy bones and joints.

Osteo Bi-Flex Joint Health, Triple Strength

 This unique combination from Osteo Bi-Flex contains glucosamine, chondroitin, MSM, other ingredients, and 5-LOXIN Advanced. This Boswellia serrata extract is special because it includes AKBA, an important boswellic acid that may aid in treating minor joint inflammation.

Nordic Naturals Ultimate Omega

Has your doctor advised you to use a pure fish oil supplement to help with your joint pain? We enjoy that this choice comes in several formats, including a liquid version. This specific option has 650 milligrams of EPA and 450 milligrams of DHA as part of 1,280 milligrams of omega-3s per two soft gel dosing, best taken with meal.
This supplement is free of artificial flavors and naturally flavored with lemon to neutralize any fishy aftertaste. Over 45,000 Amazon reviewers gave this product a 4.7-star rating (out of five stars), with many stating that the tablet is not stinky and does not cause them to burp. However, some people complain that the tablets are rather huge.

Gaia Herbs Turmeric Supreme Joint

Health This turmeric pill is designed to help support healthy joints and keep you active by minimizing occasional inflammation. The complex incorporates black pepper to help absorb curcuminoids due to piperine in black pepper increasing turmeric’s bioavailability. This vegan and gluten-free combination also contains ginger and a few additional herbal components for functional advantages. One of them is the organic Devil’s Claw root, a plant demonstrated to relieve joint discomfort.
Gaia Herbs tests every component and final product in their labs to ensure purity, integrity, and efficacy. You may examine the test results for their turmeric supplement on their website by entering the Herb ID found on the product’s packaging. This supplement has passed heavy metal, pesticide, and strength tests.

Kirkland Signature Extra Strength Vitamin D3 2000 I.U.

Vitamin D is a necessary component that aids the body’s calcium absorption, a building block for healthy bones. Limited data shows that vitamin D supplements may assist with osteoarthritis symptoms such as joint discomfort. Supplementation may be recommended if your doctor has taken your bloodwork and discovered that you have a vitamin D deficit.

This extra-strength vitamin D pill from Costco’s Kirkland brand is incredibly good quality despite its low price. Each pill has 2,000 IU of vitamin D3, and the container includes 600 doses.

How did we choose the best joint supplements?

Our certified dietitians extensively assess supplements based on nutritional knowledge, ingredients, and third-party testing data.

When choosing the best joint supplements, we evaluated dose, serving size, price, servings per container, ingredients, form, and whether the vitamin may be taken with or without a meal. We examined over 30 joint supplements to provide alternatives for various personal preferences and pricing ranges. We attempted to provide options with a variety of nutrients and substances to fulfill a variety of demands.

We highlighted suggestions that have been evaluated by a competent third-party agency for purity, potency, and safety, as well as items with strong internal quality control requirements. We examined marketing claims, ingredient listings, and product quality.

What to Look for When Purchasing the Best Joint Supplements

Finding the correct joint supplement for you and your specific requirements might be difficult. Here are a few things to consider while looking for one:

Type: Several joint health supplements are available, ranging from single nutrient supplements like vitamin D to more complicated complexes, including functional components. Speak with your doctor to determine the best option for you.

Form and size: Consider the serving size and the size of the pill itself. Are you happy with taking one huge tablet daily, or would you prefer to take many smaller ones throughout the day to fulfill your needs? Many joint supplements have huge serving sizes or hefty tablets. Is powdered or liquid form more convenient for you? Determine what is most appropriate for you and your lifestyle.

Price: The cost of best joint supplements may vary widely, and more costly ones aren’t always better. Furthermore, since each bottle includes a different number of pills and serving size might vary, we provided the cost per dose information so you can fairly evaluate each alternative.

Quality: Examine the components to confirm that the supplement has no fake additions. Third-party testing by trustworthy organizations, such as USP, NSF, or, is also crucial to establishing quality standards and that what is on the product label is what you’ll be ingesting.

What nutrients are beneficial to joints?

Joint health supplements often include several substances. Among the main ones are:

Glucosamine: A naturally occurring chemical in the body, the connective tissue cushions the ends of bones inside joints.

Chondroitin: A chemical found in cartilage surrounding joints that aids in water retention.

Fish oil combines fish’s two primary omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid.

Methylsulfonylmethane (MSM): It is an organic form of sulfur that may lower pain and swelling while improving symptoms in osteoarthritic patients.

Boswellia: This extract is made from the Boswellia tree’s bark resin, also known as frankincense. A preliminary study suggests it may reduce joint pain in at least eight weeks.

Turmeric: A root vegetable that includes the polyphenol curcumin, the primary chemical that gives it its vivid yellow color. It also has anti-inflammatory properties, which limited studies suggest may help with joint discomfort.

Collagen: It is a protein prevalent in the body and gives structure and support to muscles, bones, connective tissues, and other tissues. Chascomes in several forms, but type II has shown protreatingtment of osteoarthritis.

Hyaluronic acid: A gel-like material that aids in the lubrication and formation of cartilage and bone. It is also available as an oral supplement and as an injectable to assist in decreasing joint inflammation.

Do joint supplements have any side effects?

The majority of components included in joint supplements are widely acknowledged as safe. However, consulting with a healthcare professional is advisable to ensure that the chosen product suits your medical circumstances and prescription regimen. For instance, individuals on anticoagulant medications may get counsel from their healthcare provider against using joint supplements containing glucosamine, chondroitin, and similar constituents.

While these supplements are typically well-tolerated, they may sometimes lead to moderate adverse effects such as nausea, heartburn, and gastrointestinal disturbances, including diarrhea or constipation. This is notably seen in supplements containing glucosamine and chondroitin. Consuming most of these solutions with meals is advisable to enhance absorption and reduce the likelihood of experiencing gastrointestinal discomfort.

Another factor to consider is allergies, particularly shellfish sensitivities since many joint supplements are sourced from these sources. There are several vegan choices that we have listed on our list.

Risks of Joint Health Supplements

Most dietary supplements are safe for human use since they contain essential vitamins necessary for bodily functions. It is essential to thoroughly study supplements before use, particularly for those concurrently using medicine. Even though vitamins are often considered beneficial for health, it is important to be aware that some vitamins have the potential to interact with prescription drugs. Therefore, it is advisable to ascertain such interactions before their use.

Checking with your doctor is always a good idea since they can help you determine which supplements are right for you

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